Project 147: Molecular Biology of Lymphoma and Targeted Therapies

Contact Information

Prof. Weili Zhao      

Email: zhao.weili@yahoo.com

Project Description and Objectives:

The laboratory is working to delineate the molecular mechanism in the pathogenesis of lymphoma, precision diagnostics of lymphoma, as well as the development of novel targeted cancer therapies. The major research areas include: (1) Comprehensive investigation of lymphoma pathogenesis and identification of molecular markers. We conduct studies on the mechanisms of lymphoma development from multiple perspectives, including genomics, epigenetics, and metabolomics. Our goal is to identify molecular markers closely associated with disease progression and to reveal their roles in lymphoma biology. (2) Development of molecular classification systems and innovative diagnostic technologies. By tailoring molecular classification systems to Chinese patients, we aim to address the unique characteristics of lymphoma in this population. We also focus on advancing precision molecular pathological diagnostic technologies to provide more accurate and reliable tools for lymphoma diagnosis. (3) Translation of biological findings into targeted clinical therapies. Building on our studies of the biological functions of molecular markers and their regulation through key cellular signaling pathways, we aim to develop novel strategies for targeted lymphoma therapies. These efforts bridge the gap between fundamental research and clinical applications, ultimately contributing to improved treatment outcomes for lymphoma patients.

Eligibility Requirements

Basic knowledge of genetics and molecular biology.

Main Tasks

Bioinformatic analysis, animal model establishment, identification and characterization of anti-cancer compounds.

Website

Lab:http://daoshi.shsmu.edu.cn/Pages/TeacherInformationView.aspx?uid=81632D99-E972-4C32-BE57-BEB38105B212&from=s&pId=105101&tId=

School: https://www.shsmu.edu.cn