Project 141: Developing New Glyco-Biomarkers for Immunotherapy Response in Lung Cancer

Contact Information:

Prof. Yan Zhang    

Email: yanzhang2006@sjtu.edu.cn

Project Description and Objectives:

Glycosylation is one of the most important post-transcription modifications of proteins. Changes in glycosylation can significantly modulate the structure, stability and function of proteins and it is closely associated with pathogenesis and progression of cancer. It is found that the most routinely used cancer biomarkers, including CEA, AFP, PSA, CA125, and CA19-9 are all glycoproteins. Currently, glycosylation-based biomarkers have emerged as promising candidates for early diagnosis, prognosis and real-time follow-up of tumor dynamics. Lung cancer is the leading cause of cancer incidents and mortality worldwide. In recent years, the rise of immunotherapy has significantly improved the prognosis of lung cancer. However, only 25-30% of patients could benefit from this therapy. Thus, the discovery of the efficient biomarkers for immunotherapy response is of great importance for precise medicine. In this project, we are combining the advanced glycomics technologies with other approaches such as glycobiology and cell biology to find the new predictors of response to immunotherapy.

Eligibility Requirements:

Applicants should have basic knowledge of biology.

Experience in biological research would be an advantage.

Main Tasks:

Carry out experiments and analyze experimental results.

Give two research presentations, (one on previously published papers, one on research progress).

Finish a research report.

Website:

Lab: http://glycolab.sjtu.edu.cn/Default.aspx

School: http://116.62.6.201:8086/