Project 140: Mechanisms of New Targets in Tumor Metastasis and Development of Therapeutic Methods
Contact Information:
Prof. Fang Guo
Email: fguo@sjtu.edu.cn
Project Description and Objectives:
Our lab focuses on searching for drug targets which can inhibit tumor metastasis. The earlier work has indicated that AEP had a great effect on breast cancer metastasis. Thus, the later work will focus on searching for small molecule inhibitors of AEP, antitumor prodrugs, and therapeutic antibodies. In addition, the later work will provide depth on the mechanism of AEP in a tumor microenvironment and a tumor-associated macrophage.
This project mainly focuses on searching for the inhibitors of Bcl-2 (including natural products and derivatives) and setting up appropriate tumor animal models to study the efficacy and molecular mechanism of microwave hyperthermia chemotherapy and microwave hyperthermia immunotherapy. With clinical trials, our research will provide theoretical support for the new tumor therapy.
Eligibility Requirements:
The interested student should have a basic knowledge of Molecular biology technology.
Main Tasks:
Complete a research report.
Give two research presentations (1. References review; 2. Technical presentation).
Submit one paper to journal as a co-author.
Website:
Lab: N/A
School: http://scsb.sjtu.edu.cn/xtswyx/homeen.do?method=getHomeList