Project 139: Discovery and Preclinical Studies of Anti-Psoriasis Small Compounds
Contact Information:
Prof. Honglin Wang
Email: honglin.wang@sjtu.edu.cn
Project Description and Objectives:
Psoriasis is a chronic inflammatory skin disorder affecting 2-3% of the general population. Importantly, psoriasis is not fatal but incurable, which means patients must live with the annoying disease throughout their lifetime. Natural compounds have become an important source for new drug discovery, and there is growing international interest in lead compounds found in plants. Therefore, it is an effective way to screen active anti-psoriasis natural products derived from plants, and to derivatize natural, to determine their structures, to improve efficacy, specificity, and to reduce toxicity.
In this program, we also aim to perform preclinical studies. Deciding whether a drug is ready for clinical trials (the so-called move from bench to bedside) involves extensive preclinical studies that yield preliminary efficacy, toxicity, pharmacokinetics, and safety information. Wide doses of the drug are tested using in vitro (test tube or cell culture) and in vivo (animal) experiments, and it is also possible to perform in silico profiling using computer models of the drug-target interactions.
Eligibility Requirements:
An eligible candidate should be self-motivated and have
An excellent team spirit.
Good English communication and writing skills.
Basic knowledge of cell biology and immunology.
Experience in working with animal models is preferred.
Main Tasks:
Animal model establishment.
Small molecule screening.
Drug candidate application.
Disease score evaluation.
Druggability assessment.
Website:
Lab: http://sii.shsmu.edu.cn/DetailMemberInfo.php?pid=6&cid=22&num=22&id=11