Project 135: Mapping New Causal Genes for Glomerulonephritis

Contact Information:

Prof. Jingyuan Xie

Project Description and Objectives:

This lab focuses on mapping new causal genes in patients with glomerulonephritis based on our large biobank for glomerulonephritis during the last decade. The laboratory has three major research interests, including: (1) Identification of rare variants for glomerulonephritis including FSGS and IgA nephropathy (IgAN) by next-generation sequencing, (2) Identification of common variants associated with glomerulonephritis such as focal segmental glomerulosclerosis (FSGS) and Membranous nephropathy (MN) by genome-wide association studies, (3) In vivo (trans-genetic animal models) and in vitro functional studies (variant cultured cell lines) that are performed for novel mutations to reveal their exact pathogenic mechanism. Through the above research, we aim to better understand the genetic basis of glomerulonephritis and contribute to precision medicine for patients in the near future.

Eligibility Requirements:

Basic knowledge of genetics, statistics and molecular biology.

Main Tasks:

The familial study, sequencing data analysis, and an in vitro functional study (cell experiment)

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