Project 110: Assessment of Dopamine Neuron Number in the Mouse Models of Parkinson’s Disease
Contact Information:
Assoc. Prof. Ilya A. Vinnikov
Email: i.vinnikov@sjtu.edu.cn
Project Description and Objectives:
Parkinson’s disease is the most prevalent neurodegenerative movement disorder with tremor, rigidity, bradykinesia and postural instability. These symptoms develop upon progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. MicroRNAs are essential during the development of most tissues, including the dopaminergic system. The rapidly emerging field of microRNA has already suggested several molecular mechanisms relevant to the pathogenesis of PD. However, the comprehensive functional analysis of specific microRNAs in dopaminergic neurons is still missing.
The objective of the proposed project is to identify the physiological and pathophysiological functions of midbrain-expressed microRNAs in a neurodegenerative context. The project will involve the counting of adult dopaminergic neurons in the in vivo models of Parkinson’s disease. In particular, we will implement genetically engineered mice with over-expression of Dicer, the endonuclease crucial for microRNA maturation. The data generated as a result of this project might aid both neurologists and researchers studying the mechanisms of neurodegenerative diseases.
Eligibility Requirements:
Background knowledge in image analysis, computer sciences, molecular biology, biochemistry or neuroscience is an asset.
Main Tasks:
Image analysis and neuronal number quantification.
Website:
School: http://life.sjtu.edu.cn/