Project 102: Enantioselective Addition of Inactivated Alkenes

Contact Information:

Prof. Yongqiang Tu

Project Description and Objectives:

Selective functionalization of the carbon−carbon double bond in olefins provides a tremendous number of fundamental transformations that hold widespread applications in organic synthesis and exert a great impact on the development of organic chemistry. Transition metal catalysis is one of the most important tools to accurately forge chemical bonds in modern organic synthesis. Organocatalysis, a biomimetic catalyst that usually catalyzes with metal-free small organic molecules, is a relatively young research area that started to flourish at the beginning of this century. In this project, we will investigate the enantioselective addition reaction of inactivated alkenes enabled by transition metal/organocatalysis cooperative catalysis, resulting in successive multiple bond-forming events, further forming useful building blocks that exist extensively in bioactive molecules and pharmaceuticals.

Eligibility Requirements:

Basic knowledge of organic chemistry.

Motivation to work and an interest in organic synthesis chemistry.

Majors in organic chemistry preferred.

Main Tasks:

Finish a research report.

Submit a paper to a conference or a journal as a co-author.

Website:

Lab: N/A

School: http://scce.sjtu.edu.cn/en/