Project 98: Surface-enhanced Raman spectroscopy for Metabolomics and Disease Early Diagnosis

Contact Information

Prof. Jian Ye

Project Description and Objectives

Disease early diagnosis is of great concern in clinics and will highly benefit the patients. Metabolites are a kind of important disease biomarkers to indicate the disease-related physiological status in addition to the nucleic acids and the proteins, and have been recently attracted a lot of attentions from scientists. However, metabolites are typically detected via the mass spectrometer but shows few clinical potentials due to the high cost of the equipment and time-consuming pre-treatment process.

This project will focus on surface-enhanced Raman scattering (SERS)-based digital colloid-enhanced Raman spectroscopy (dCERS) (Nature, 2024) and SERSome (Cell Reports Medicine, 2024) technique for rapid and sensitive metabolomics analysis of the biofluids. This technique is based on the molecule-fingerprinting spectral nature with the advantage of ultra-high throughput and single-molecule sensitivity. With the targeting the biomarkers, SERS technique, as the non-targeting, non-invasive and efficient technique, will pave a new way of the accurate disease diagnosis and basic pathological studies with high practical and popularizing value.

Eligibility Requirements

Background in biomedical nanomaterials and clinical diagnosis

Prerequisite of biomedical statistics and basic algorithms for data analysis

Enthusiasm to advancing the in vitro diagnostics (IVD) techniques

Main Tasks

Synthesis and optimization of SERS nanomaterials for metabolite detection

Practicing SERS measurements of the biofluids

Developing and optimization of the algorithms for spectral analysis and bioinformatics

Writing final reports.

Website

Lab: http://www.yelab.sjtu.edu.cn/

School: https://bme.sjtu.edu.cn/