Our lab focus on searching for drug targets which can inhibit tumor metastasis. The earlier work has indicated that AEP had great effect on breast cancer metastasis. Thus, the later work will focus on searching small molecule inhibitors of AEP, antitumor prodrug, and therapeutic antibody. In addition, the later work will provide in-depth on the mechanism of AEP in tumor microenvironment and tumor-associated macrophage.
Our lab focus on searching for the inhibitors of Bcl-2 (including natural products and derivatives), setting up appropriate tumor animal models to study efficacy and molecular mechanism of microwave hyperthermia chemotherapy and microwave hyperthermia immunotherapy. With clinical trials, our research will provide theoretical support for the new tumor therapy.