Project 89: Surface-enhanced Raman spectroscopy for accurate disease diagnosis
Contact Information:
Prof. Jian Ye
Email: yejian78@sjtu.edu.cn
Project Description and Objectives：
Accurate diagnosis is of great concern in clinics and a technique that can realize early diagnosis will especially benefit the patients. However, a high level of heterogeneity makes the examination on single molecular targets or tissue pieces extremely limited. Multiple metabolites detection, which provides a comprehensive metabolic profile of a biological system, can be leveraged to indicate the disease-related physiological status and has the potential in discovering the biomarkers that are likely to be overlooked before.
This project will focus on using surface-enhanced Raman scattering (SERS) to directly probe the detailed metabolites in the biofluids based on the molecule-fingerprinting spectral nature with the advantage of ultra-high throughput and single-molecule sensitivity. SERS technique, as the non-targeting, non-invasive and efficient technique, will pave a new way of the accurate disease diagnosis and basic pathological studies with high practical and popularizing value.
Eligibility Requirements：
l Background in biomedical nanomaterials and clinical diagnosis
l Prerequisite of biomedical statistics and basic algorithms for data analysis
l Enthusiasm to advancing the in vitro diagnostics (IVD) techniques
Main Tasks：
l Synthesis and optimization of SERS nanomaterials for metabolite detection
l Practicing SERS measurements of the biofluids
l Developing and optimization of the algorithms for spectral analysis
l Writing final reports.
Website:
Lab: http://www.yelab.sjtu.edu.cn/
School: https://bme.sjtu.edu.cn/