Project 119: Discovery, Synthesis and Biological Evaluation of Mitochondrial Targeting Drugs

Contact Information:

Prof. Lei Fu

Email: leifu@sjtu.edu.cn

Project Description and Objectives:

Mitochondria are essential organelle in the cells. The research on mitochondria-targeting drugs is one of the hottest study fields. In our previous research, we discovered a lead compound, TPP-thiazole, which can target Mitochondria and mitigate metabolic syndrome of aging. In this project, we will discover mitochondria-targeting drugs from traditional Chinese medicine or through chemical synthesis, and then evaluate their biological activities.

Eligibility Requirements:

Basic knowledge on biology or chemistry.

Main Tasks:

Extraction of active components form traditional Chinese medicine; Chemical synthesis of compounds; Cellular biological experiments.

Website:

Lab: N/A

School: http://pharm.sjtu.edu.cn/en