Project 108: The study on the pathogenesis of depression
Contact Information:
Asso.Prof. Weidong Li
Email: liwd@sjtu.edu.cn
Project Description and Objectives:
There is an increasing risk of mental disorders, such as acute stress disorder (ASD), post-traumatic stress disorder (PTSD) and depression among survivors who were trapped in rubble during earthquake. Such long-term impaction of a single acute restraint stress has not been extensively explored. Our studies found subjected mice to 24-hour-restraint to simulate the trapping episode, and also we discovered a potential target gene LHPP which play a critical role in depression. Lateral habenula nucleus (LHb), the central of Amygdala (CeA) and anterior cingulate cortex (ACC) has been reported associated with depression. In this project, we will explore the neuron function in LHb, CeA and ACC of depressive-like mice induced by acute stress (24-hour-restraint) and LHPP knock-out using multi-channel recording , voltage sensitive detection imagine, Transcranial magnetic stimulation and whole cell recording. This project may provide a clue for the study of pathogenesis of depression.
Eligibility Requirements:
Understanding of lab safety.
Interested students should have basic knowledge of Neurophysiology and signal processing.
Main Tasks:
Finish a research report.
Give two research presentations.
Website:
Lab: https://lwdlab.sjtu.edu.cn/
School: